2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Opioid Receptor

Opioid Receptor

Opioid Receptor

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Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Isoform Specific Products:

Opioid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13243S1
    Alvimopan-d7
    		Antagonist
    Alvimopan-d7 (ADL 8-2698-d7) is deuterium labeled Alvimopan. Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus.
    Alvimopan-d<sub>7</sub>
  • HY-113683
    AZ 12488024
    		Agonist
    AZ 12488024 (AZD7268) is a SNC80 (HY-101202) derivative and a δ-opioid receptor agonist. AZ 12488024 is available for research into major depressive disorder.
    AZ 12488024
  • HY-19206
    R-84760
    		Agonist
    R-84760 is a selective κ-opioid receptor agonist. R-84760 has antinociceptive effect.
    R-84760
  • HY-101307
    BNTX maleate
    		Antagonist
    BNTX (7-Benzylidenenaltrexone) maleate is a δ1-opioid receptor antagonist with the Kis of 0.1, 10.8, 13.3, and 58.6 nM for δ1, δ2-, μ-, and κ-opioid receptor, respectively. BNTX maleate shows antinociceptive activity.
    BNTX maleate
  • HY-169469
    N-Phenethylnoroxymorphone
    		Ligand
    N-Phenethylnoroxymorphone is an opioid compound. N-Phenethylnoroxymorphone enhances morphine-induced analgesia in rats. N-Phenethylnoroxymorphone can be used for research on neurological diseases.
    N-Phenethylnoroxymorphone
  • HY-129933
    (+)-Norpropoxyphene maleate
    (+)-Norpropoxyphene maleate is an opioid metabolite and is a metabolite of Propoxyphene.
    (+)-Norpropoxyphene maleate
  • HY-156992
    AT-035
    		Agonist
    AT-035 is a high affinity and selective NOP agonist.
    AT-035
  • HY-168816
    Dipyanone hydrochloride
    Dipyanone hydrochloride is structurally similar to known opioids.
    Dipyanone hydrochloride
  • HY-120927A
    Alvimopan metabolite hydrochloride
    		Antagonist
    Alvimopan metabolite hydrochloride is a peripherally restricted Opioid Receptor antagonist that inhibits the amplitude of electrically evoked contractions and spontaneous mechanical activity in guinea pig ileum.
    Alvimopan metabolite hydrochloride
  • HY-130367
    U-48520
    		Agonist
    U-48520 is an agonist for μ-opioid receptor with EC50 of 1561 nM.
    U-48520
  • HY-13274A
    JTC-801 free base
    		Antagonist
    JTC-801 free base is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2?nM.
    JTC-801 free base
  • HY-119914
    Bromadol
    Bromadol is an opioid.
    Bromadol
  • HY-137920
    Salvinorin A propionate
    		Agonist
    Salvinorin A (Divinorin A) propionate is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A propionate is a non-nitrogenous neoclerodane isolated from Salvia divinorum.
    Salvinorin A propionate
  • HY-P1625
    Daeatal
    Daeatal (Dynorphin A ethylamide (1-9)) is an ethylamine-modified dynorphin fragment that can be used in the study of analgesia, addiction, depression, etc. Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease.
    Daeatal
  • HY-W714505
    AH 7563
    		Ligand
    AH 7563 structurally belongs to the opioid compounds and exhibits analgesic activity. In the phenylquinone test and hot plate test, the ED50 of AH 7563 for analgesia in mice were 15.3 mg/kg (orally) and 15.5 mg/kg (subcutaneous injection), respectively.
    AH 7563
  • HY-168818
    N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride
    N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride is structurally similar to known opioids.
    N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride
  • HY-162548
    Homprenorphine
    		Inhibitor
    Homprenorphine is an opioid alkaloid derivative, structurally related to Cyprenorphine.
    Homprenorphine
  • HY-B1485
    Nalmefene hydrochloride
    		Antagonist
    Nalmefene hydrochloride is a long acting opioid (MOR and DOR antagonist), and a partial KOR agonist. Nalmefene hydrochloride is used for opioid overdose and alcohol dependence.
    Nalmefene hydrochloride
  • HY-118987
    AT-127
    		Agonist
    AT-127 is a NOP receptor partial agonist, stimulating NOP/G-protein interaction in a concentration dependent manner.
    AT-127
  • HY-158899
    3,4-Ethylenedioxy U-51754 hydrochloride
    3,4-Ethylenedioxy U-51754 hydrochloride is structurally similar to known opioids.
    3,4-Ethylenedioxy U-51754 hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Opioid Receptor Isoform Comparison

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