2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Opioid Receptor

Opioid Receptor

Opioid Receptor

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Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.

Opioid Receptor Isoform Specific Products:

Opioid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-172149
    Naltrindole 5′-isothiocyanate
    		Antagonist
    Naltrindole 5′-isothiocyanate (5'-NTII) is a non-selective delta opioid receptor antagonist that can antagonize the analgesic effects induced by DSLET (HY-P1332) without affecting the analgesic effects induced by DPDPE (HY-P1334).
    Naltrindole 5′-isothiocyanate
  • HY-121854
    Bromadoline
    Bromadoline is a utopioid with antinociceptive activity in rodents.
    Bromadoline
  • HY-162570
    Volazocine
    Volazocine is an opioid benzomorphane derivative with potential analgesic activity.
    Volazocine
  • HY-W725295
    1-(5-Fluoropentyl)-1H-indazole-3-carboxylic acid
    1-(5-Fluoropentyl)-1H-indazole-3-carboxylic acid is structurally similar to known synthetic cannabinoid metabolites.
    1-(5-Fluoropentyl)-1H-indazole-3-carboxylic acid
  • HY-123142
    RX809055AX
    		Antagonist
    RX 809055AX is a potent long lasting opioid antagonist with selectivity towards at mu and delta receptors.
    RX809055AX
  • HY-A0118S1
    Naloxegol-13C,d2
    		Antagonist
    Naloxegol-13C,d2 (NKTR-118-13C,d2) is 13C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation.
    Naloxegol-<sup>13</sup>C<sub>,d<sub>2</sub>
  • HY-W725190
    Piperidylthiambutene hydrochloride
    Piperidylthiambutene hydrochloride is an opioid with analgesic activity in animal models.
    Piperidylthiambutene hydrochloride
  • HY-15536B
    Cebranopadol hemicitrate
    		Agonist
    Cebranopadol hemicitrate is an analgesic NOP and opioid receptor agonist with Kis/EC50s of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, 18 nM/110 nM for human NOP, MOP, KOP and delta-opioid peptide (DOP) receptor, respectively. Cebranopadol hemicitrate can be used for acute and chronic pain study.
    Cebranopadol hemicitrate
  • HY-106601
    Picenadol
    Picenadol (LY-150720) is a racemic opioid that can be used in combination with other opioids. Picenadol has anticholinergic activity.
    Picenadol
  • HY-13243S1
    Alvimopan-d7
    		Antagonist
    Alvimopan-d7 (ADL 8-2698-d7) is deuterium labeled Alvimopan. Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus.
    Alvimopan-d<sub>7</sub>
  • HY-113683
    AZ 12488024
    		Agonist
    AZ 12488024 (AZD7268) is a SNC80 (HY-101202) derivative and a δ-opioid receptor agonist. AZ 12488024 is available for research into major depressive disorder.
    AZ 12488024
  • HY-19206
    R-84760
    		Agonist
    R-84760 is a selective κ-opioid receptor agonist. R-84760 has antinociceptive effect.
    R-84760
  • HY-101307
    BNTX maleate
    		Antagonist
    BNTX (7-Benzylidenenaltrexone) maleate is a δ1-opioid receptor antagonist with the Kis of 0.1, 10.8, 13.3, and 58.6 nM for δ1, δ2-, μ-, and κ-opioid receptor, respectively. BNTX maleate shows antinociceptive activity.
    BNTX maleate
  • HY-169469
    N-Phenethylnoroxymorphone
    		Ligand
    N-Phenethylnoroxymorphone is an opioid compound. N-Phenethylnoroxymorphone enhances morphine-induced analgesia in rats. N-Phenethylnoroxymorphone can be used for research on neurological diseases.
    N-Phenethylnoroxymorphone
  • HY-129933
    (+)-Norpropoxyphene maleate
    (+)-Norpropoxyphene maleate is an opioid metabolite and is a metabolite of Propoxyphene.
    (+)-Norpropoxyphene maleate
  • HY-156992
    AT-035
    		Agonist
    AT-035 is a high affinity and selective NOP agonist.
    AT-035
  • HY-168816
    Dipyanone hydrochloride
    Dipyanone hydrochloride is structurally similar to known opioids.
    Dipyanone hydrochloride
  • HY-120927A
    Alvimopan metabolite hydrochloride
    		Antagonist
    Alvimopan metabolite hydrochloride is a peripherally restricted Opioid Receptor antagonist that inhibits the amplitude of electrically evoked contractions and spontaneous mechanical activity in guinea pig ileum.
    Alvimopan metabolite hydrochloride
  • HY-123689R
    Samidorphan (Standard)
    		Modulator
    Samidorphan (Standard) is the analytical standard of Samidorphan. This product is intended for research and analytical applications. Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo.
    Samidorphan (Standard)
  • HY-123689R
    Samidorphan (Standard)
    		Antagonist
    Samidorphan (Standard) is the analytical standard of Samidorphan. This product is intended for research and analytical applications. Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo.
    Samidorphan (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Opioid Receptor Isoform Comparison

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